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Experimental transfusion in rabbits, guinea-pigs, rats, and mice of systemic lupus erythematosus plasma

Experimental transfusion in rabbits, guinea-pigs, rats, and mice of systemic lupus erythematosus plasma

Annals of the Rheumatic Diseases 21: 76-78

ISSN/ISBN: 0003-4967

PMID: 13867061

DOI: 10.1136/ard.21.1.76

Plasma transfusion experiments were carried out on 609 rabbits, guinea-pigs, rats, and mice, with plasma obtained from three patients with S. L. E. Serum from these patients had enabled the L. E.-cell phenomenon to be transferred to man and dog, but this transfer was not effected in the 609 animals, even with much greater amounts of transfused plasma, reckoned in ml./kg. body weight. In chronic experiments on 21 guinea-pigs, no L. E.-cell phenomenon was produced, even after repeated transfusions of plasma, and no change characteristic of S. L. E. was found either histologically or by laboratory investigation.

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Accession: 024663800

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