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Fine structure of the Rauscher leukemia virus as revealed by incubation in snake venom

Fine structure of the Rauscher leukemia virus as revealed by incubation in snake venom

Virology 30(4): 623-630

Purified Rauscher leukemia virus was incubated in reconstituted lyophilized snake venom. Examination of the negatively stained venom-treated virus preparations showed the outer envelopes of most of the particles to be ruptured, revealing capsids the circumference of which showed 25-30 capsomeres 100 A in length and 75-80 A in width. Prolonged incubation in venom resulted in modification of the capsids of most of the particles and revealed a shell or framework penetrated with holes arranged in a hexagonal array. These results suggest that the capsids of Rauscher leukemia virus are covered with a coat of material which is removed by incubation in snake venom.

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Accession: 024694961

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PMID: 5951648

DOI: 10.1016/0042-6822(66)90167-X

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