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Genetic effects on fine structure and development of pigment granules in mouse hair bulb melanocytes: II. The c and ploci, and ddpp interaction



Genetic effects on fine structure and development of pigment granules in mouse hair bulb melanocytes: II. The c and ploci, and ddpp interaction



Develop Biol 17(4): 366-381



This study dealt with the effects of mutation at the p (pink-eyed dilution) and c (albinism) loci separately, and at the p and d (Maltese dilution) loci together, on the fine structure of brown and black melanin granules in hair bulb melanocytes of the house mouse. Mutation at the p locus affects size, degree of melanization, and, in bb cells, shape of the granules. pp granules are lightly melanized and are smaller than PP granules, apparently because they fail to enlarge after the beginning of melanization. The c allele does not prevent the formation of granule framework, but does prevent melanization. Occasional cc granules are as large as heavily melanized granules of the corresponding CC genotype. The c and p alleles have 2 effects in common. Both produce in bb granules a shift toward the pattern of longitudinal strands and membranes characteristic of BB granules. Both also cause the occurrence in the melanocyte of round membrane-enclosed bodies of variable internal structure which may be granules in the process of disintegration. In cc melanocytes these effects are so marked that BBcc cells cannot be reliably distinguished from bbcc. The addition of Maltese dilution to pink-eyed dilution counteracts, though incompletely, the decrease of granule melanization, but intensifies the shift toward the black pattern.

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