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Genetic effects on fine structure and development of pigment granules in mouse hair bulb melanocytes: L The b and d loci



Genetic effects on fine structure and development of pigment granules in mouse hair bulb melanocytes: L The b and d loci



Develop Biol 17(4): 351-365



Mutation at the b locus affects both shape and structure of the granules. BB granules are oval, and the structure of the unmelanized granules consists of 1 or more rolled membranes. bb granules are round, and their internal framework resembles a tangled ball of strands. The principal effect of the d allele on the melanocyte is an increase in the number of granules present, apparently resulting from prolonged retention of granules by the melanocyte. This accumulation is not attributable to any visible property of granule structure or formation. The distribution of unmelanized granules within the melanocyte suggests that both Golgi vesicles and free ribosomes are involved in granule formation. The largest melanized granules in all 4 genotypes are larger than the largest unmelanized granules, but it is not clear whether growth occurs only by increase in thickness of the melanin deposit or whether there is an addition of new framework.

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