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Genetic, cytochemical, cytoenzymatic investigations and molecular biochemistry in Pelger-Huet anomaly

Genetic, cytochemical, cytoenzymatic investigations and molecular biochemistry in Pelger-Huet anomaly

Rev Roumaine Med Intern 2(5): 421-426

A series of investigations were made with the object of elucidating the mechanism of production of " Pelger-Huet" anomaly. They have examined the karyotype of 6 carriers of the heterozygote anomaly. No deviation from normal was found. In the cytochemical and cytoenzymatic examinations, a decrease of leukocytic alkaline phosphatase was observed. Chromatographic and spectral examinations were made RNA isolated from medullary cells.

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Accession: 024744039

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