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Growth processes in cartilage and bone subsequent to gonadectomy and administration of anterior pituitary extract of cattle in immature male and female guinea pigs



Growth processes in cartilage and bone subsequent to gonadectomy and administration of anterior pituitary extract of cattle in immature male and female guinea pigs



American Journal of Pathology 15(1): 55-72.7



In immature guinea pigs gonadectomy causes an increased proliferation of the euhyaline cartilage in various cartilaginous tissues. In [male][male] hyperplastic growth is more accentuated, whereas in [female][female], a more pronounced tendency to hypertrophy is present. The latter is especially evident within the joint, where arthro-pathic lesions are initiated more readily than in [male][male]. In [female][female] degeneration occurs more frequently and to a greater extent than in ??. Calcification and ossification of the cartilage appear balanced in [female][female, but in [male][male] marked disturbances are observed in the zone of ossification. Associated with these disturbances is a tendency to fibrosis of the bonemarrow. The cause of the increased proliferation is seen in a nonspecific stimulation of the ant. pituitary subsequent to gonadectomy. Differences in the behavior of the sexes are tentatively explained as due to differences in the inhibiting action of the gonads on the pituitary glands in [male] and [female] and also to differences in the action of gonadectomy on the thyroid gland in the 2 sexes. A combination of the action of acid extract of ant. pituitary of cattle and of castration leads to a summation effect which is determined by different degrees of stimulation exerted in the various tissues.

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Accession: 024763633

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PMID: 19970433


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