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Hematological studies on schistosomiasis mansoni in Puerto Rico Estudios hematologicos sobre la esquisto-somiasis de manson en Puerto Rico

Molina, R.R.; Pons, J.A.

Puerto Rico Jour Public Health And Trop Med 11(3): 369-400, 401-433

1936


Accession: 024774832

20 human cases of schistosomiasis were observed: one case in the toxemic stage, 8 in the intestinal, and 11 cases in the late visceral. In a few cases blood studies were continued during and after treatment. Erythro-cytes, leukocytes, platelets, differential white cell counts and reticulocytea were enumerated; hemoglobin, volume of packed red cells, mean corpuscular volume, corpuscular hemoglobin and corpuscular conc. were determined. Fouadin, in addition to iron, seems to be the treatment of choice in the toxemic and intestinal stages of the disease, as moderate anemia, when present, is of the hypochromic microcytic type, and apparently due to an iron deficiency. In the late stage of the disease the degree of anemia is greater than that observed in the intestinal stage. Two types of specific deficiency anemias were found in this stage: one, hypochromic-mierocytic or normocytic due to iron deficiency, and the other macrocytic, probably due to the deficiency in the specific antianemic factor of liver. Iron and liver extract are palliative in the late stage, as the patient is suffering from cirrhosis of the liver, a condition resulting from the long and continued host-parasite relationship. Several months following removal of the spleen in two cases in the late stage of the disease there was a marked clinical improvement but with slight hypochromia and reduction in the number of red cells in both cases. The macrocytic anemia of cases studied in the late stage, may be due to a deficiency in the specific antianemic factor conditioned by chronic liver cirrhosis and not necessarily by gastric dysfunction.

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