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Histochemical studies on acid and alkaline phosphatases of radium irradiated and nonirradiated squamous cell carcinoma of uterine cervix



Histochemical studies on acid and alkaline phosphatases of radium irradiated and nonirradiated squamous cell carcinoma of uterine cervix



Chinese Jour Pathol 5(2): 84-87



Activity of acid and alkaline phosphatases of squamous cell carcinoma of cervical biopsies from 51 cases was studied by means of Gomori's histochemical method, 13 had been treated with radium irradiation, while 38 were untreated. In nonirradiated group, various amounts of acid and alkaline phosphatases were present in tumor cells. The amount of phosphatase was closely related to degree of differentiation and state of growth of tumor tissue. In infiltrating cords of tumor tissue alkaline phosphatase reaction was stronger. In radium irradiated group, activity of acid and alkaline phosphatases showed a regular dynamic change. Before any noticeable histologic change occurred, both acid and alkaline phosphatases increased for a certain duration, and then with occurrence of degeneration and necrosis of tumor tissue, they decreased or even completely disappeared. Activity of acid and alkaline phosphatases of capillaries and inflammatory cells of irradiated cervical carcinoma, especially alkaline phosphatase in granulation tissue, showed stronger reaction than that of nonirradiated carcinomas. Reaction of nonmalignant cervical tissue (e.g. chronic endocervicitis) was very weak. Multinucleated giant cells which appeared after irradiation showed only strong reaction of acid phosphatase.

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