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Histochemical studies on gastric cancer and other gastric diseases: with special references to the genesis of gastric cancer and the interstitial reaction of gastric cancer tissue



Histochemical studies on gastric cancer and other gastric diseases: with special references to the genesis of gastric cancer and the interstitial reaction of gastric cancer tissue



Ann Rept Res Inst Tuberc Kanazawa Univ 20(2): 53-66



In 16 gastric ulcer, 12 chronic gastritis, 3 gastric polyp, 16 ulcer cancer, 18 gastritis cancer and 8 polyp cancer cases, the alkaline and acid phosphatase activity, RNA and DNA reactions, PAS reaction, and lipase activity were examined in the tissues. In the gastric ulcer and ulcer cancer, the increase of alkaline phosphatase activity was recognized in the superficial layer of the mucosa and glandular cells at the edge of the ulcer, the callous tissue, the interstitial connective tissue and the cancer cells. On the other hand, in chronic gastritis and gastritis cancer, the decrease of alkaline phosphatase activity was observed in the superficial layer and glandular cells of the gastric mucosa, the interstitial connective tissue and the cancer cells. The decrease was especially noticeable in atrophic gastritis. In all the tissues of ulcer cancer, gastritis cancer and polyp cancer, the increase of DNA and RNA reactions was clearly seen in the adjacent mucosa, the interstitial connective tissue and the cancer cells. It was worthy of notice that the phosphatase activity, DNA and RNA reactions, and PAS reaction increased conspicuously in the region where the atypia or the malignant changes of the regenerated epithelium were shown at the edge of the gastric ulcer. On the other hand, in the cirrhotic type of gastric cancer accompanied by the strong interstitial reaction, the increase of alkaline phosphatase activity was observed in the interstitial connective tissue as well as in the cancer cells. It was interesting that this phenomenon might be regarded as a defensive reaction of the host to the cancer.

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