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Hypertensive disease of the brain



Hypertensive disease of the brain



Arch Path 36(3): 289-296



The characteristic histologic features of hypertensive encephalopathy observed in 25 cases are reported and 2 cases are described. Typical vascular alterations, confined to the arterioles and capillaries were observed in all cases and described under the heading of "hypertensive hyaline arteriolopathy." These arteriolar changes consisted of hyaline degeneration and fibrotic thickening of the vessel walls associated with narrowing or. obliteration of the lumens. They should be considered as different from arteriosclerosis. A working hypothesis presumes that the characteristic vascular changes may be due to functional vascular disturbances of prolonged duration or of repeated occurrence. Changes in the parenchyma of the brain consisted of diffusely scattered circumscribed small foci of old and recent softening, perivascular hemorrhage, massive hemorrhage and diffuse or localized edema of the brain. The alteration of the brain tissue is secondary to the arteriolar lesions.

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Accession: 024811135

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DOI: 10.1097/00005053-193710000-00026


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