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Immune serum globulin in the prophylaxis of paralytic poliomyelitis measles infectious hepatitis hypogammaglobulinemia. The distribution and use of gamma globulin. A statement issued April 20, 1953, by the Division of Medical Sciences of the National Research Council. Plan for the allocation of gamma globulin. Issued April 15, 1953, by the Office of Defense Mobilization in the Executive Office of the President. Progress in research on poliomyelitis, by HARRY M. WEAVER



Immune serum globulin in the prophylaxis of paralytic poliomyelitis measles infectious hepatitis hypogammaglobulinemia. The distribution and use of gamma globulin. A statement issued April 20, 1953, by the Division of Medical Sciences of the National Research Council. Plan for the allocation of gamma globulin. Issued April 15, 1953, by the Office of Defense Mobilization in the Executive Office of the President. Progress in research on poliomyelitis, by HARRY M. WEAVER



Publ Health Repts 68(7): 659-677



[I] It is estimated that about 1,000,000 average doses of gamma globulin will be available for the prophylaxis of poliomyelitis during 1953. The selection of the group of individuals in which this limited supply of material can be used most effectively presents many epidemiological and administrative problems. Four alternative methods have been recommended by the Division of Medical Sciences, National Research Council, and have been incorporated in the allocation plan adopted by the Office of Defense Mobilization. The advantages and disadvantages of these methods in particular situations are reviewed. The allocation plan is based on the principle that the local health officer is in the best position to decide which method of prophylaxis will most effectively meet each local situation as it arises. The household contact plan would appear to be the most effective in areas of low or moderate incidence, with possible extension to include intimate contacts other than family members. With high epidemic incidence in a community with an intense outbreak, either community prophylaxis of age groups particularly susceptible or extension of the household contact plan to include contacts of suspected cases may be suitable. Factors such as community size, expected severity and duration of the epidemic, facilities for the injection of large numbers of individuals and the availability of gamma globulin may influence the decision as to the plan for emphasis in a particular area. The plans are of sufficient latitude, however, to apply to almost any situation, and appear to offer some hope of restricting the use of the scarce material to the groups at greatest risk.

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