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Immune serum production in poliomyelitis refractory animals



Immune serum production in poliomyelitis refractory animals



Jour Immunol 26(2): 93-118



3 guinea pigs, 4 rabbits, 1 dog, 2 sheep, 1 goat and 1 horse were given repeated injections of suspensions of ground poliomyelitic cords for ca. 6-24 mos. Virucidal tests were carried out on the sera of these animals during and after the period of more intensive virus injections by mixing 1 cc of virus suspension with an equal volume of undiluted or previously diluted serum, following which the serum-virus mixtures were injected intracerebrally into monkeys. Titrationa of the virus suspension and serum were carried out in several cases. Results confirmed the observations of others with reference to the degree in which poliomyelitis-refractory animals respond as antiserum producers, the majority responding poorly or not at all to virus injections. Individual animals may respond well. The horse proved exceptionally responsive, eventually yielding a serum containing sufficient immune substance per cc to neutralize at least 25,000 M.I.D. of virus.

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Accession: 024821108

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DOI: 10.3181/00379727-28-5139


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