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Immunological studies on old tuberculin sensitized erythrocytes. 12. Significance of the reticuloendothelial system in immunization with OT-sensitized red cells. II. The effect of various pretreatments given to the reticuloendothelial system on the distribution of OT-sensitized red cells in different organs



Immunological studies on old tuberculin sensitized erythrocytes. 12. Significance of the reticuloendothelial system in immunization with OT-sensitized red cells. II. The effect of various pretreatments given to the reticuloendothelial system on the distribution of OT-sensitized red cells in different organs



Ann Rept Res Inst Tuberc Kanazawa Univ 17(1): 65-78



In non-immunized rabbits, neither india ink blockade nor splenectomy had any noticeable effect on the survival of injected old tuberculin (OT) sensitized cells. The survival time of OT-sensitized red cells injected into rabbits immunized with OT-sensitized autologous red cells and then splenectomized is less than in nonimmunized ones, but somewhat greater than in immunized animals with their spleens intact. X-ray irradiation reduced the life of OT-sensitized red cells in the blood stream when the dosage was 50 r, but prolonged it when the dosage was 600 r. Sheep red cells, OT-sensitized sheep red cells and OT-sensitized autologous red cells survived longer when injected into animals previously given 5 injections of Cr51-labeled OT-sensitized sheep red cells than when the animals had received nonlabeled OT-sensitized sheep red cells. When Cr51-labeled, OT-sensitized autologous red cells were injected into normal rabbits the Cr51 showed a tendency to accumulate in the liver, spleen and bone marrow, while with Cr51-labeled sheep red cells the Cr51 was quickly excreted through the kidney. When labeled OT-sensitized autologous red cells were injected into rabbits immunized with OT-sensitized red cells, the Cr51 was quickly excreted through the kidney, but their livers showed higher concentration of Cr51 than the livers of nonimmunized animals. Splenectomy did not seem to exercise any influence on the distribution of Cr51 in other organs, either in those animals which had been immunized with OT-sensitized red cells or in nonimmunized ones, following injections of labeled OT-sensitized autologous red cells or labeled sheep red cells.

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