+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Induction Of Atheroma In Renal Arteries Of Rabbits



Induction Of Atheroma In Renal Arteries Of Rabbits



Archives of Pathology 76: 667-676



The main renal artery in man is comparatively free of atherosclerosis; renal arteries of hypercholesterolemic rabbits with extensive aortic atheromatosis are normally free of plaques. Lipid plaque deposition was induced in the renal arteries of hypercholesterolemic rabbits by producing atrophy of the associated kidney. Total ligation of 1 renal vein in 1 or 2 stages resulted in various degrees of renal atrophy; subtotal ligation resulted in little or no atrophy because of the development of abundant collateral venous drainage. None of the animals became hypertensive. Rabbits with atrophic kidneys and marked aortic atheromatosis developed intimal plaques in the renal arteries on the ligated side; animals with marked aortic lesions but without renal atrophy had no renal artery plaques. The arteries supplying the hyperplastic contralateral kidneys had no plaques. These observations suggest that hemodynamic changes accompanying unilateral kidney atrophy were responsible for the selective deposition of plaques in the associated renal artery.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 024844622

Download citation: RISBibTeXText

PMID: 14059386

DOI: 10.1001/jama.1963.03710110101075


Related references

Atheroma of the renal arteries. Angeiologie 19(3): 49-58, 1967

The significance of atheroma of the renal arteries in Kimmelstiel-Wilson's syndrome. Journal of Pathology and Bacteriology 64(1): 103-120, 1952

The occurrence of atheroma in the aorta in rabbits with renal hypertension. Arch Path 33(5): 655-660, 1942

8b.03: Atheroma Progression In Renal Arteries After Catheter-Based Renal Artery Denervation Using Serial Volumetric Computed Tomography Analysis: Analysis From The Enlightn 1 Trial. Journal of Hypertension 33 Suppl 1(): E107-E108, 2015

Evaluation of renal arteries with use of gadoterate meglumine-, CO(2)-, and iodixanol-enhanced DSA measurements versus histomorphometry in renal artery restenosis in rabbits. Journal of Vascular and Interventional Radiology 12(6): 747-752, 2001

Angiographic study of the accessory renal arteries (superior and inferior polar arteries independent of the normal renal arteries) and their pathological significance. Lyon Chirurgical 61(5): 685-702, 1965

Arterial Supply Of The Mouse Kidney. Statistical Studies On The Variations Of The Renal Arteries, The Anterior And Posterior Branches Of The Renal Arteries And Of The Subcortical Arteries. Anatomischer Anzeiger 116: 101-115, 1965

Renal cortical accumulation of phenobarbital in rats and rabbits: lack of correlation with induction of renal microsomal monooxygenases. Journal of Pharmacology and Experimental Therapeutics 220(3): 547-551, 1982

Evaluation of spiral computed tomography of the renal arteries alone or combined with Doppler ultrasonography in the detection of renal artery stenosis. Prospective study of 114 renal arteries. Archives des Maladies du Coeur et des Vaisseaux 88(8): 1159-1164, 1995

Fate of accessory renal arteries in grafts with multiple renal arteries during live-donor renal allo-transplantation. Transplantation Proceedings 45(3): 1232-1236, 2013

The effect of beta -sitosterol on cholesterol-induced atheroma in rabbits with high blood pressure. The effect of a brief period of high blood pressure on cholesterol-induced atheroma in rabbits. Brit. J. Exp. Pathol, 38: 49-54, 1957

Endothelium-dependent relaxation in isolated renal arteries of diabetic rabbits. Autonomic & Autacoid Pharmacology 22(2): 73-82, April, 2002

Endothelium-dependent relaxation in isolated renal arteries of diabetic rabbits. Autonomic & Autacoid Pharmacology 22(2): 73-82, 2003

Effect of constriction of the renal arteries in pregnancy and in certain endocrine states of rabbits. Arch Path 31(1): 68-81, 1941