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Infection in laboratory animals with pleuropneumonia-like organisms

Infection in laboratory animals with pleuropneumonia-like organisms

Journal of the National Cancer Institute 20(5): 911-919

Organisms of the pleuropneumonia group (PPLO) are widely distributed in rats and mice and many different types are recognized. Infectious catarrh, a chronic disease that involves the nasal passages, middle ears, and lungs, is produced by PPLO in rodents. The disease is transmissible by direct contact and is prevalent in breeding colonies. Other organs in mice or rats, which PPLO may frequent naturally or experimentally, are the conjunctiva, the brain, the joints, and the female genitalia. Localization of the organisms is usually attended by an infiltration of leukocytes and exudation. PPLO are recoverable from all loci of involvement by cultivation on nutrient agar enriched with horse serum.

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Accession: 024847145

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PMID: 13539637

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