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Infection in laboratory animals with pleuropneumonia-like organisms

Journal of the National Cancer Institute 20(5): 911-919

Infection in laboratory animals with pleuropneumonia-like organisms

Organisms of the pleuropneumonia group (PPLO) are widely distributed in rats and mice and many different types are recognized. Infectious catarrh, a chronic disease that involves the nasal passages, middle ears, and lungs, is produced by PPLO in rodents. The disease is transmissible by direct contact and is prevalent in breeding colonies. Other organs in mice or rats, which PPLO may frequent naturally or experimentally, are the conjunctiva, the brain, the joints, and the female genitalia. Localization of the organisms is usually attended by an infiltration of leukocytes and exudation. PPLO are recoverable from all loci of involvement by cultivation on nutrient agar enriched with horse serum.

Accession: 024847145

PMID: 13539637

Related references

Kuzell, W.C.; Mankle, E.A., 1960: Cultivation of pleuropneumonia like organisms in Reiter's disease, including one instance of laboratory cross infection. Annals of the New York Academy of Sciences 79: 650-657

Ito, Shogo, 1960: Distribution of pleuropneumonia-like organisms among human and animals. Isolation of PPLO from 372 human beings, 443 mice, 64 rats, 328 guinea pigs, 188 rabbits, 58 sand mice, 45 hamsters, 34 monkeys, 89 cattle, 79 horses, 45 sheep and 67 pigs was carried out during 4 years. Samples were taken from the oral cavity, na...

Kenny, G.E.; Pollock, M.E., 1963: Mammalian cell cultures contaminated with pleuropneumonia-like organisms. I. Effect of pleuropneumonia-like organisms on growth of established cell strains. Journal of Infectious Diseases 112: 7-16

Stokes, E.J., 1955: Human infection with pleuropneumonia-like organisms. Lancet 268(6858): 276-279

Edward, D.G., 1952: The pleuropneumonia group of organisms and their significance in genital infection. From a review of the literature on the pleuropneumonia group of organisms and their significance in genital infection, Edward makes the following conclusion: "Organisms of the pleuropneumonia group have been isolated from the discharge in cas...

Hanko, E.; Otterlin, S.E., 1955: An outbreak of infection with pleuropneumonia-like organisms in goats and sheep in Sweden.. Of 41 goats and 3 sheep on a Norrland farm, 21 goats and one sheep became infected. Six goats'died. Symptoms resembled those of pleuro-pneumonia and mastitis. The disease was controlled by slaughter of the remaining animals. No cases occurred...

Villemot, J.-M.; Provost, A., 1959: Immunological studies on pleuropneumonia. VI. Serological classification of pleuropneumonia-like organisms. Gel precipitation tests and agglutination tests were performed with 12 different antisera and antigens prepared from PPLO strains from man, cattle and goats and also an American strain isolated from turkeys with encephalitis. The results are tabul...

Pegreffi, G.; Mura, D.; Contini, A., 1958: Ovine contagious pleuropneumonia caused by pleuropneumonia-like organisms. The disease affected sheep of both sexes and of any age with a mortality of 30-40% in adults and 85-90% in lambs aged 30-40 days. It occurred during autumn and winter after lambing. Clinically, it was subacute or chronic, characterized by anorexia...

Anonymous, 1960: Immunization of laboratory animals with streptococci I With organisms killed by heat II With living virulent organisms under protection by antibiotics

Fahey, J.E.; Crawley, J.F., 1956: Studies On Chronic Respiratory Disease Of Chickens. VII. The Nature Of Infection With The Pleuropneumonia-Like Organisms. Evidence accumulated by the inoculation of chick embryos and chicks with pleuro-pneumonia-like organisms (PPLO) from cases of "chronic respiratory disease" is presented to show that PPLO produce a syndrome indistinguishable from Type II...