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Influence of the ventilation changes on the degree of the alveolar-capillary diffusion capacity for the CO. Effect of a bronchodilating aerosol in both normal and pneumopathic subjects



Influence of the ventilation changes on the degree of the alveolar-capillary diffusion capacity for the CO. Effect of a bronchodilating aerosol in both normal and pneumopathic subjects



Lavoro Umano 18(9): 398-416



The pulmonary ventilation and the alveolar-capillary diffusion capacity was studied by a CO method (Bates' method) in basal conditions and after administration of a bronchodilating aerosol. The research was carried out in 20 normal subjects, 30 patients with chronic bronchitis and 40 with silicosis. The The DCO [pulmonary diffusing capacity for CO] values prove to be reduced in basal conditions, in a statistically significant degree in comparison with the normal subjects; in the patients with chronic bronchitis the DCO reduction results to be closely related to ventilation changes; such a correlation is not found in silicotic patients. An increase of the DCO values is observed after bronchodilating aerosol. This is more marked in pneumopathic subjects with more severe changes of the bronchospastic type.

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