Inhibitory postsynaptic membrane specializations are formed in gephyrin-deficient mice
O'Sullivan, G.Adrianus.; Hofer, W.; Betz, H.
Neuroscience Letters 458(3): 106-110
Gephyrin is a major postsynaptic scaffolding protein at GABAergic and glycinergic inhibitory synapses. Gephyrin-deficient (geph(-/-)) mice die after birth due to disinhibition of motor and sensory pathways resulting from a lack of postsynaptic glycine receptor and GABA(A) receptor clusters. Here, immunoelectron and confocal microscopy revealed that postsynaptic membrane specializations are formed in the absence of gephyrin.