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Inhibitory postsynaptic membrane specializations are formed in gephyrin-deficient mice

O'Sullivan, G.Adrianus.; Hofer, W.; Betz, H.

Neuroscience Letters 458(3): 106-110

2009

ISSN/ISBN: 0304-3940
PMID: 19383528
DOI: 10.1016/j.neulet.2009.04.036
Accession: 024870720
Gephyrin is a major postsynaptic scaffolding protein at GABAergic and glycinergic inhibitory synapses. Gephyrin-deficient (geph(-/-)) mice die after birth due to disinhibition of motor and sensory pathways resulting from a lack of postsynaptic glycine receptor and GABA(A) receptor clusters. Here, immunoelectron and confocal microscopy revealed that postsynaptic membrane specializations are formed in the absence of gephyrin.

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Related References

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Kneussel, M.; Brandstätter, J.H.; Laube, B.; Stahl, S.; Müller, U.; Betz, H. 1999: Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice Journal of Neuroscience: the Official Journal of the Society for Neuroscience 19(21): 9289-9297
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