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Inhibitory postsynaptic membrane specializations are formed in gephyrin-deficient mice

O'Sullivan, G.Adrianus.; Hofer, W.; Betz, H.

Neuroscience Letters 458(3): 106-110

2009


ISSN/ISBN: 0304-3940
PMID: 19383528
DOI: 10.1016/j.neulet.2009.04.036
Accession: 024870720

Gephyrin is a major postsynaptic scaffolding protein at GABAergic and glycinergic inhibitory synapses. Gephyrin-deficient (geph(-/-)) mice die after birth due to disinhibition of motor and sensory pathways resulting from a lack of postsynaptic glycine receptor and GABA(A) receptor clusters. Here, immunoelectron and confocal microscopy revealed that postsynaptic membrane specializations are formed in the absence of gephyrin.

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