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Interaction experiments on the responses evoked by Purkinje cells by climbing fibers

Interaction experiments on the responses evoked by Purkinje cells by climbing fibers

J Physiol 182(2): 297-315

The uniquely powerful excitatory synaptic action of a single climbing fiber on a Purkinje cell in the cerebellum of the cat was tested during the intense and prolonged inhibitory action produced by the parallel fiber, basket and stellate cell system. There was depression of the later spike discharges, but the initial discharge was never suppressed. With intracellular recording the excitatory post-synaptic potential was depressed during the initial phase (about 10 msec) of the inhibitory action, but there was a later increase with a time course resembling the latter part of the inhibitory hyperpolarization. The excitatory action of a climbing fiber synapse is greatly depressed immediately after a preceding activation and recovery takes hundreds of milliseconds. By the collision technique it is shown that the same climbing fiber is activated by inferior olive and juxtafastigial stimulation. With rapid repetitive activation there was initially a progressive decline in the effectiveness of each successive impulse, but a steady level was soon reached. On cessation of a tetanus of 20 or more impulses there was a delayed recovery of the depolarization, which suggests a continued action of the accumulated transmitter. With extracellular recording repetitive spike initiation continued with stimulation frequencies as high as 100/sec, but at still higher frequencies spikes were depressed by the intense synaptically evoked depolarization. On cessation of the stimulation after-discharge often developed as the depolarization declined. The prolonged after-discharges following severe tetani suggest that there is a very effective accumulation of the transmitter.

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Accession: 024881653

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PMID: 5942031

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