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Chapter 24,894

Intrinsic factor antibodies and intrinsic factor mediated vitamin B-12 absorption in pernicious anaemia

Ardeman, S.; Chanarin, I.

Gut 6(5): 436-438

1965

ISSN/ISBN: 0017-5749
PMID: 5321462
DOI: 10.1136/gut.6.5.436
Accession: 024893504
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Absorption of vitamin B12-Co57, measured by urinary excretion, was potentiated to a greater extent by intrinsic factor preparations from hogs than from humans, in patients with perniciuos anemia. This difference was not found in post-gastrectomy patients. An antibody to human intrinsic factor is postulated to be present in cells of intestinal villi in pernicious anemia.

Related References

Neumann, E.; Honetz, N. 1972: Antibodies against intrinsic factor after treatment of pernicious anaemia with highly purified pig intrinsic factor-vitamin B-12 complex by mouth Blut 24(1): 6-11
Hift, W.; Moshal, M.G.; Pillay, K. 1973: Megaloblastic anaemia, achlorhydria, low intrinsic factor, and intrinsic-factor antibodies in the absence of pernicious anaemia Lancet 1(7803): 570-573
Rose, M.S.; Chanarin, I. 1971: Intrinsic-factor Antibody and Absorption of Vitamin B12 in Pernicious Anaemia BMJ 1(5739): 25-26
Neumann, E.; Honetz, N. 1972: Antibodies against intrinsic factor in oral treatment of pernicious anemia with highly purified hog intrinsic factor-vitamin B 12 complex Blut 24(1): 6-11
Ungley, C.C. 1950: Absorption of vitamin B12 in pernicious anaemia. I. Oral administration without a source of intrinsic factor British Medical Journal 2(4685): 905-908
Ungley, C.C. 1950: Absorption of Vitamin B12 in Pernicious Anaemia: I. Oral Administration Without a Source of Intrinsic Factor BMJ 2(4685): 905-908
Schwartz, M.; Lous, P.; Meulengracht, E. 1957: Effects of intrinsic factor on absorption of vitamin B12 in. patients with pernicious anaemia treated by mouth for a long time Ugeskr. Lceger. 119: 899-904
Wangel, A.G.; Callender, S.T.; Spray, G.H.; Wright, R. 1968: A family study of pernicious anaemia. II. Intrinsic factor secretion, vitamin B12 absorption and genetic aspects of gastric autoimmunity British Journal of Haematology 14(2): 183-204
Ungley, C.C.; Childs, G.A. 1950: Absorption of vitamin B12 in pernicious anemia. III. Failure of fresh milk or concentrated whey to function as Castle's intrinsic factor or to potentiate the action of orally administered vitamin B12 British Medical Journal 2(4685): 911-915
Cummins, D.; Ardeman, S. 1991: Intrinsic factor antibodies and pernicious anaemia Lancet 338(8763): 383-384
Berlin, H.; Berlin, R.; Brante, G.; Sjoberg, S.G. 1958: Studies on intrinsic factor and pernicious anemia. I. Oral uptake of vitamin B12 in pernicious anemia with increasing doses of an intrinsic factor concentrate Scandinavian Journal of Clinical and Laboratory Investigation 10(3): 278-282
Berlin, H.; Berlin, R.; Brante, G.; Sjöberg, S.G. 1961: Studies on Intrinsic Factor and Pernicious Anemia: Iii. Intrinsic Factor Activity and B 12 -Binding Power of Electrophoretic Fractions of Intrinsic Factor Concentrates Scandinavian Journal of Clinical and Laboratory Investigation 13(2): 245-248
Sjoberg, S G. 1961: Studies on intrinsic factor and pernicious anemia, II Intrinsic factor activity and B12 -binding power of electrophoretic fractions of intrinsic factor concentrates Scandinavian Jour Clin And Lab Invest: 245-248
Berlin, H.; Berlin, R.; Brante, G.; Sjoberg, S.G. 1961: Studies on intrinsic factor and pernicious anemia. 3. Intrinsic factor activity and Bi2-binding power of electrophoretic fractions of intrinsic factor concentrates Scand. J. Clin. Lab. Invest 13: 245-248
Berlin, H.; Berlin, R.; Brante, G.; Sjöberg, S.G. 1958: Studies on Intrinsic Factor and Pernicious Anemia: I. Oral Uptake of Vitamin B 12 In Pernicious Anemia with Increasing Doses of an Intrinsic Factor Concentrate Scandinavian Journal of Clinical and Laboratory Investigation 10(3): 278-282
Rose, M.; Chanarin, I.; Doniach, D.; Ardeman, S.; Brostoff, J. 1970: Intrinsic factor antibodies in the absence of pernicious anaemia Clinical Science 38(4): 23p
Wolff, R.; Tamisier, C.; Nicolas, J.P. 1970: Cross reactions of pig intrinsic factor with anti intrinsic factor blocking antibodies present in the serum of some patients with pernicious anemia Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 164(6): 1330-1334
Kaise, W. 1970: Cross reactions with pig intrinsic factor of anti human intrinsic factor antibodies type ii present in the sera of some pernicious anemia patients Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 164: 1384-1387
Shanahan, R. 1954: The role of oral vitamin B12 and intrinsic factor in pernicious anaemia Journal of the Irish Medical Association 35(209): 337-341
Cooper, B.A.; Yates, T. 1967: Antibody to intrinsic-factor-vitamin-B 12 complex in pernicious anaemia British Journal of Haematology 13(5): 687-694