Intrinsic factor antibodies and intrinsic factor mediated vitamin B-12 absorption in pernicious anaemia
Ardeman, S.; Chanarin, I.
Gut 6(5): 436-438
ISSN/ISBN: 0017-5749 PMID: 5321462 DOI: 10.1136/gut.6.5.436
Absorption of vitamin B12-Co57, measured by urinary excretion, was potentiated to a greater extent by intrinsic factor preparations from hogs than from humans, in patients with perniciuos anemia. This difference was not found in post-gastrectomy patients. An antibody to human intrinsic factor is postulated to be present in cells of intestinal villi in pernicious anemia.