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Investigations on 3-antipyrine derivatives. II. Transformations of the ethyl ester of 3-antipyrine 4-dithiocarboxylic acid

Janik, B.; Kocwa, A.; Zagala, I.

Dissertations Pharmaceut 10(2): 143-149

1958


Accession: 024899916

The derivatives of l-phenyl-2,5-diethyl-3-pyrazolone (the so called 3-antipyrine) ethyl ester of 4-dithiocarboxylic acid of 3-antipyrine, when heated with a calculated amount of KOH undergoes saponification forming a mixture of the 4-dithiocarboxylic acid and 4-thiocarboxylic acid of 3-antipyrine; when heated with a large excess of base it leads to the transformation of the ethyl ester of the 4-dithiocarboxylic acid of 3-antipyrine into the 5-mercapto derivative of l-phenyl-2-methyl-4-acetyl-3-pyrazolone. These transformations of the ethyl ester of the 4-dithiocarboxylic acid of 3-antipyrine exhibit complete similarity to the already known behavior of the ethyl ester of the 4-dithiocarboxylic acid of antipyrine.

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