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Measles vaccination: III. Serologic responses to immunization with purified hemagglutinin

Measles vaccination: III. Serologic responses to immunization with purified hemagglutinin

Acta Paediat Scand 54(6): 581-586

A comparative study was made of the immunizing effect of purified measles hemagglutinin (TE vaccine) and a formalinized, alum-adsorbed, whole virus preparation (FK vaccine). Three monthly doses of 1.01 ml vaccine were given to 2 groups comprising 40 and 31 children, respectively . Both vaccines gave 100% conversions with almost identical mean neutralization (about 1:180) and HI [hemagglutination inhibition] srum (about 1:600) titers. A difference was found in the CF [complement fixation] tests. The frequency of CF conversion was 80% with the FK vaccine and only 32.5% with the TE vaccine. Blood samples collected 11 months after the administration of the last dose of vaccine were submitted to sero-logical analysis. HI antibodies were still present on a detectable level in 100% of the sera. The reduction in mean titers was 8.5 and 10.6 fold in groups of children given the FK and TE vaccine, respectively. No known exposure to measles occurred during the time of observation. However, 6 months after vaccination one child given the FK vaccine contracted what most likely was mild measles.

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