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Measles vaccine field trials in Alaska. L Killed vaccine followed by live attenuated vaccine and gamma-globulin with live attenatuated vaccine



Measles vaccine field trials in Alaska. L Killed vaccine followed by live attenuated vaccine and gamma-globulin with live attenatuated vaccine



J American Medicine Assoc 189(5): 339-342



Two regimens of measles vaccination were tested in Alaskan Eskimo villages in March, 1963. Clinical reactions to vaccines were no more severe than those observed in other populations. From 7 to 11 days following administration of live attenuated vaccine plus gamma-globulin, 18% of vaccinees had a temperature of 103 F (39.4 C) and 24% developed a rash. One dose of killed vaccine followed in 6 weeks by live attenuated vaccine produced a temperature of 102 F (38.9 C) in only 2 instances and measles-like rash was not observed. Height of antibody response following live attenuated vaccine and gamma-globulin was related significantly to age and maximum temperature. Rash occurred more frequently in the very young.

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