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Metabolic studies in patients with cancer of the gastrointestinal tract. XIII. The effect of glycine on the urinary excretion of creatine and creatinine, especially by patients with cancer of the gastrointestinal tract



Metabolic studies in patients with cancer of the gastrointestinal tract. XIII. The effect of glycine on the urinary excretion of creatine and creatinine, especially by patients with cancer of the gastrointestinal tract



Cancer Res 4(3): 145-148



The intraven. adm. of glycine to normal subjects and to patients with benign gastrointestinal disorders was uniformly followed by increased urinary excretion of creatine and creatinine. The intraven. adm. of comparable amts. of glycine to patients with gastrointestinal cancer and hepatic cirrhosis in 21 to 25 instances failed to increase their urinary output of creatine and creatinine. The simultaneous ingestion of choline, as a source of free methyl groups, failed to increase the creatine and creatinine excreted in the urine of patients with gastrointestinal cancer or hepatic cirrhosis. The possibility is presented that the failure of glycine to increase the output of creatine and creatinine in the urine of patients with gastrointestinal cancer is due to their coexisting hepatic insufficiency.

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