Modification of radiation-induced intestinal injury in rats by chilling after irradiation
Gude, W.D.; Upton, A.C.; Odell, T.T.
International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine 1: 247-255
Chilling of the small intestine of the rat immediately after x-irradiation postponed depression of the mitotic count and degeneration of the crypt cells. Mitotic depression and cellular degeneration occurred, however, when the tissue was re-warmed. The effects of transient chilling at 18[degree]C were essentially identical to those of chilling at 5[degree]C. The inhibition of colchicine-induced metaphase arrest and of tritiated thymidine uptake in chilled crypt cells suggests that postponement of the signs of radiation injury resulted from suppression of metabolic activity and cell division at low temperature. Although there was some suggestion of reduced injury in the chilled tissues, the protective or recovery-promoting effectiveness of hypothermia remains to be established.