Modifications of the pathogenic activity of several bacteria treated by chemical substances

Pelletier, M.; Delaunay, A.; Bazin, S.

Ann Inst Pasteur 109(1): 105-117


Accession: 025027949

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Bacteria (Staphylococcus, Salmonella typhimurium, Proteus morganii), when treated in vitro, in determined conditions, by some chemical substances such as: Pn (a polypeptide complex extracted from calf thymus), CaCl2, trypsin or lysozyme, are still alive, but their pathogenic activity is greatly modified. Bacteria, treated by PII, CaCl2 or trypsin, are less pathogenic. Bacteria, treated by lysozyme, are more pathogenic. Such modifications are increased or decreased when bacteria are successively treatedby twoof these substances. Such modifications however are only transitory. When treated bacteria are cultivated on usual media, they rapidly become again normally pathogenic. These results are briefly discussed.