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Morphological aspects of renal tubular transport. I. Electron microscopy of the proximal tubule cells of rabbit kidney during the process of sodium p-aminohippurate transport



Morphological aspects of renal tubular transport. I. Electron microscopy of the proximal tubule cells of rabbit kidney during the process of sodium p-aminohippurate transport



Med Jour Osaka Univ 11(3): 241-263



Proximal tubule cells of the rabbit kidney were observed electronmicroscopically during the process of active transport of PAH. Effects of simultaneous administration of certain substances which influence tubular excretion were also studied. Main changes following the intravenous administration of doses exceeding transport maxima of PAH were involution of the basal cell membranes, appearance of endoplasmic reticulum along these membranes and dissociation between these membranes. Simultaneous administration of stimulatory substances of PAH transport, such as acetate, caused extension of the peritubular space between the infolded basal cell membranes and the appearance of numerous cytoplasmic pedicles at the cell base as the result of the elaborate infolding of the membrane. The subdivided cytoplasm seems to have developed as a specifically differentiated organization to increase the available active sites at which PAH may combine with certain cellular components. Administration of substances, such as 2,4-dinitrophenol, sodium mono-fluoroacetate, sodium malonate, and large amount of sodium citrate which were shown to block the active transport of PAH, caused mito-chondrial destruction and diminished the basal cell surface by inhibiting the involution of the base cell membranes.

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