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On the distribution velocity of parenterally administered homologous tetanus antitoxin



On the distribution velocity of parenterally administered homologous tetanus antitoxin



Progr Immunobiol Stand 2: 117-124



A single dose of 250 units of human tetanus antitoxin in the form of human hyperimmune globulin obtained by a modified neutral salt frac-tionation procedure was injected intramuscularly (4 subjects) and for control purposes intravenously (1 subject). Serum samples were taken during the 1st 3 post-injection days in closer spaced intervals and thereafter in wider intervals up to 14 days. The mean values of serum antitoxin levels were compared with the hypothetical disappearance rate. Equilibrium conditions were reached between 1 and 2 days; after a steep initial increase of serum titers the actual disappearance function was coincident with the predicted slope. The implications of these findings for the practical use of intramuscularly administered human antitoxin are discussed.

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