On the nature of tick-borne encephalitis virus, II. A comparative study of nucleic acids and specific antigen in cells from brains of white mice infected with tick-borne encephalitis virus by fluorescence microscopy
Sokolov, N.N.; Parfanovich, M.I.; Mekler, L.B.
Acta Virol 7(3): 217-224
1963
Accession: 025165688
During experimental tick-borne encephalitis in white mice a parallelism between the distribution of RNA-containing material and specific antigen could be demonstrated in the neurons of the cornu Ammonis and the Purkynje cells of the cerebellum, which suggests a participation of RNA in the synthesis of tick-borne encephalitis virus antigen. The coincidence found between the production and distribution of RNA-containing material and of specific antigen demonstrated certain peculiarities of virus interaction with cells of the central nervous system, namely a specific fluorescent RNA-material in the nucleoli, its penetration through the nuclear membrane and concentration in the cytoplasm, and release from the cells.