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On The Site Of Melanin Formation In Melanocytes

On The Site Of Melanin Formation In Melanocytes

Journal of Biochemistry 54: 465-467

The rate of incorporation of 3,4-dihydroxyphenylalanine-C14 into the melanosomes, mitochondria, smooth and rough membranes of melanocytes of Harding-Passey melanoma was studied. The results revealed the following course of tyrosinase biosynthesis Tyrosinase is synthesized in ribosomes, transferred via rough membranes (endoplasmic reticulum) to Golgi area, where a small unit of tyrosinase is surrounded by a membranous envelope to form a smooth membrane, where the tyrosinase molecule becomes aligned in an ordered pattern and catalyzes the formation of melanin, which accumulates around the smooth membrane particules to form structureless melanosomes.

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Accession: 025173758

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PMID: 14089743

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