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P-Amino-N- benzamides. Potential antifibrillatory drugs

P-Amino-N- benzamides. Potential antifibrillatory drugs

J Med Chem 8(1): 107-111

The alkylation of amines with 1-p-nitro-benzoylethylenimine was studied. The p-nitro-N-[2-(substituted amino)-ethyljbenzamides were readily hydrolyzed to N- substituted ethyl -enediamines. The p-nitrobenzamides were hydrogenated catalytically and a series of analogs of procaine amide were obtained. These analogs were screened for antifibrillatory activity in the rabbit heart and in the dog heart. Several of the compounds showed high activity.

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Accession: 025196096

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