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Pancreatic islet cell tumors and renal tumors and renal tumors in the male rat following neutron exposure



Pancreatic islet cell tumors and renal tumors and renal tumors in the male rat following neutron exposure



Lab Invest 11(3): 204-210



During a study of the long term and late effects of fast neutron exposure in the rat a large number of primary pancreatic and renal neoplasms was seen at autopsy. The incidence of pancreatic islet cell tumors among non-irradiated control animals was 17% whereas the same tumor was found in 56% of the animals exposed to 230 rads and 44% of those exposed to 320 rads. The functional significance, if any, of these tumors has not been established. Most animals with islet cell tumors also had primary tumors in other endocrine tissues although no specific pattern was discernible. Renal neoplasms, in the form of adenomas, carcinomas and transitional cell carcinomas, were found in 41% of the animals exposed to 230 rads and in 43% of those exposed to 320 rads. No renal neoplasia was seen in the non-irradiated controls from the same litters. This finding suggests that renal neoplasia in these rats is a response to radiation rather than an event in the normal aging process. On a rad dose basis neutrons are more potent than X-rays for the induction of both islet cell and renal parenchymal tumors.

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Accession: 025199493

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