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Passive sensitization of human skin by sera of guinea pigs anaphylactically sensitized to ovalbumin



Passive sensitization of human skin by sera of guinea pigs anaphylactically sensitized to ovalbumin



Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 77(2): 245-247



Sera from some guinea pigs sensitized with ovalbumin produced passive sensitization of human skin, but sera from others similarly treated were inactive in this respect. All of the antisera showing skin-sensitizing activity were from guinea pigs which had survived anaphylactic shock following challenging injns. However, no antisera were obtained from these pigs before the shock dose. Hence, the effect of the challenging injn. on the formation of this type of antibody could not be assessed. The skin-sensitizing activity of the sera bore no relation to their potency in passive sensitization of guinea pigs. This observation suggests that skin-sensitization and anaphylaxis are mediated by different antibodies, the skin-sensitizing antibody being formed by only a fraction of the guinea pigs in response to a type of stimulation which consistently produced anaphylactic antibody.

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Accession: 025207264

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PMID: 14854008

DOI: 10.3181/00379727-77-18738


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