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Pathways and tissue distribution of dipyridamole

Pathways and tissue distribution of dipyridamole

Arch Int Pharmacodyn Therap 156(2): 380-388

The pathway of Persantin in the body of laboratory animals was investigated after oral ingestion. The drug is rapidly absorbed from the G. I. [gastrointestinal] tract and found in all organs except the brain. Within 3 to 4 hours, the drug content of the tissues reaches its peak. After 12 hours the organs and serum in the aorta still contain 45 to 55% of peak levels, and 70 to 80% in the serum of the portal vein. Both liver and kidney have a high concentration of Persantin, but the liver excretes it in large amounts in bile, whereas very little is eliminated in the urine. The largest amount is always found in the G. L tract; there it forms a deposit and maintains the intensive enterohepatic cycle of the drug. The concentration of Persantin in heart muscle is slightly below that of serum in the aorta. Their drug levels followed each other closely in 72 guinea pigs during a 24 hour observation period. When the drug is given intravenously to rabbits the drug content is several times higher in the serum than in the heart. However, its organ distribution is similar to that of guinea pigs.

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Accession: 025211964

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PMID: 5895707

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