Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzyme peroxiredoxin 5
Sensi, M.; Pietra, G.; Molla, A.; Nicolini, G.; Vegetti, C.; Bersani, I.; Millo, E.; Weiss, E.; Moretta, L.; Mingari, M.Cristina.; Anichini, A.
International Immunology 21(3): 257-268
ISSN/ISBN: 0953-8178 PMID: 19181932 DOI: 10.1093/intimm/dxn141
Peptides with dual binding specificity for classical HLA class I and non-classical HLA-E molecules have been identified in virus-encoded proteins, but not in cellular proteins from normal or neoplastic cells. Expression screening of a melanoma cDNA library with a CTL clone recognizing an HLA-A2-restricted tumor-specific epitope encoded by mutant peroxiredoxin 5 (Prdx5), a stress-inducible peroxidase, led to the identification of two alternatively spliced isoforms of the same gene.