+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Persistence of strain-specific behavior in two strains of Trypanosoma cruzi after prolonged transfer through inbred mice



Persistence of strain-specific behavior in two strains of Trypanosoma cruzi after prolonged transfer through inbred mice



Journal of Parasitology 35(6): 593-599



Two lethal, immunologically cross-reactive, and morphologically indistinguishable strains of T. cruzi, originally isolated from human patients, were maintained for 28 and 41 mos., respectively, by serial transfer through mice. By the use of genetically homogeneous hosts (homozygosity over 98%) of the same sex and comparable age kept on a standardized diet and infected at regular intervals with uniform inocula, the majority of variables, which enter into determining virulence levels, were controlled. The more virulent WBH strain showed a pronounced rhythmic response to seasonal temp. fluctuations, and was more susceptible to the quinoline derivative Bayer 7602 than the B-strain. These differences in behavior are interpreted as brought about entirely by the parasite's inherent strain-specific physiol. pattern, rather than by environmental variables.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 025222530

Download citation: RISBibTeXText

PMID: 15394407


Related references

Biochemical behavior of Trypanosoma cruzi strains isolated from mice submitted to specific chemotherapy. Revista Da Sociedade Brasileira de Medicina Tropical 27(4): 209-215, 1994

Immunological aspects of infection of 6 inbred strains of mice by 3 different strains of Trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz 80(2): 203-211, 1985

Wild vectors and reservoirs of trypanosoma cruzi 72. behavior of pf strain of trypanosoma cruzi in mice inoculated with flagellates obtained from triatomines infected either by artificial xeno diagnosis or inoculation into the coelomic cavity. Revista Brasileira de Biologia 39(1): 5-8, 1979

Resistance to Trypanosoma cruzi in inbred strains of mice. Abstracts of papers read at the 5th International Congress on Protozoology, New York City, 26 June 2 July, 1977: 174, 1977

Susceptibility of inbred mice to Trypanosoma cruzi strain Y. Revista do Instituto de Medicina Tropical de Sao Paulo 22(4): 192-196, 1980

Comparison of drug sensitivities of three strains of Trypanosoma cruzi in inbred A/Jax mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 75(2): 274-281, 1981

Biological characterization of clones of the Y, CL and MR strains of Trypanosoma cruzi in inbred C3H mice. Memorias do Instituto Oswaldo Cruz 83(2): 175-181, 1989

Cytokine profiles during acute Trypanosoma cruzi infection in inbred strains of mice. Journal of Immunology 150(8 Part 2): 69A, 1993

Dynamics of the phagocytic cells during the infection of two inbred strains of mice with trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz 81(Suppl.): 144, 1986

Patterns of resistance of inbred mice to Trypanosoma cruzi are determined by parasite strain. Brazilian Journal of Medical and Biological Research 18(4): 499-506, 1985

Trypanosoma cruzi: role of the immune response in the natural resistance of inbred strains of mice. Experimental Parasitology 45(2): 160-168, 1978

Lymphokine release by spleen cells from trypanosoma cruzi infected inbred strains of mice. Molecular & Biochemical Parasitology (Suppl.): 29, 1982

Trypanosoma cruzi early parasite proliferation and host resistance in inbred strains of mice. Experimental Parasitology 62(2): 194-201, 1986

Trypanosoma cruzi Cytokine mRNA expression in the hearts of pathoresistant vs pathopermissive strains of inbred mice. Journal of Eukaryotic Microbiology 44(1): 8A, 1997

Trypanosoma cruzi: in vivo and in vitro correlation between T-cell activation and susceptibility in inbred strains of mice. Experimental Parasitology 51(3): 325-334, 1981