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Physiology of the corpus luteum. V. The preparation and some chemical properties of progestin, a hormone of the corpus luteum which produces progestational proliferation



Physiology of the corpus luteum. V. The preparation and some chemical properties of progestin, a hormone of the corpus luteum which produces progestational proliferation



Amer Jour Physiol 91(1): 174-188



An improved procedure for the preparation of a hormone of the corpus luteum which produces progestational proliferation is described, and evidence is presented to show that it is destroyed by alkalies, thus differentiating it chemically from oestrin. The purified product is relatively stable to heat, mild oxidation, mild acid hydrolysis, and is not associated with cholesterol color reactions. The hormone in the crude form deteriorates rapidly, but may be kept in alcoholic solution for long periods without loss. A rabbit unit of the hormone is defined; plates showing various degrees of proliferation and data regarding the yields are given. The name "progestin" is proposed.

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Accession: 025243501

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Related references

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