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Poliomyelitis vaccine studies, an assessment of the serologic response to poliomyelitis vaccine in children following passive immunization with gamma globulin, and in tuberculous children



Poliomyelitis vaccine studies, an assessment of the serologic response to poliomyelitis vaccine in children following passive immunization with gamma globulin, and in tuberculous children



Publ Health Reports 71(6): 604-611



The serologic response of children inoculated with gamma globulin 3 days prior to active immunization with poliomyelitis vaccine was measured. The consistent rise in antibody titer in the children in the study demonstrates that passive immunization of this extent has no suppressive effect on the individual's response to the vaccine. Vaccination of children hospitalized for tuberculosis resulted in antibody levels consistent with the response of normal children and indicated that immunization of tuberculous individuals should be practiced. Effect of 2 inoculations was equally as good as that of 3 injections, and no significant difference was observed in the response of 1-to 5-year old children as compared with that of older children, 6- to 12-years of age. The booster effect of secondary vaccination almost 1 year later is demonstrated and discussed.

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