+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Radical external radiation therapy of localized prostatic carcinoma

Radical external radiation therapy of localized prostatic carcinoma

Tenth International Congress of Radiology Book of Abstracts, Montreal, Quebec, Canada No 923(b) p 273

Kerr and Flocks have demonstrated that primary carcinoma of the prostate responds to irradiation derived from the interstitial application of radioactive colloidal gold. Furthermore, it has been estimated that in about 40 percent of the patients with carcinoma of the prostate the neoplasm is limited to the prostate, capsule or pericapsular region. Thus, while most of such patients are not candidates for radical prostatectomy, their relatively localized disease is ideally suited for local irradiation. It seemed to us that the prostatic region might be more homogenously irradiated by a well-collimated supervoltage external source, such as the Stanford Medical Linear Accelerator, than by an interstitial radioisotope. Since 1956, approximately 60 patients with localized but non-resectable carcinoma of the prostate have been treated. The technique depends upon accurate localization of the tumor and beam direction in order to develop a rotational isodose pattern. Two to six year follow-up on about the first 45 patients treated in this manner demonstrated that local control of the disease was possible in approximately 80 percent of the cases, while in about 50 percent no further evidence of neoplasm, either local or metastatic, was detected. These results compare favorably with those obtained by radical perineal prostatectomy, even though prostatectomy is usually applied to earlier lesions. In most patients the treatment was tolerated exceedingly well. The selection of patients, technique, follow-up and analysis of complications will be presented in detail. With the availability of well-collimated supervoltage devices expanding rapidly, it is hoped that this method of treatment may become available to an increasing number of patients.

(PDF emailed within 1 workday: $29.90)

Accession: 025336189

Download citation: RISBibTeXText

Related references

Assessment of outcome prediction models for patients with localized prostate carcinoma managed with radical prostatectomy or external beam radiation therapy. Cancer. 82(10): 1887-1896, 15, 1998

Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 280(11): 969-974, 1998

External radiation therapy of localized prostatic cancer. Journal of the National Medical Association 76(1): 61-66, 1984

Biochemical outcome after radical prostatectomy or external beam radiation therapy for patients with clinically localized prostate carcinoma in the prostate specific antigen era. Cancer 95(2): 281-286, 2002

Ultrasonically guided 125iodine seed implantation with external radiation in management of localized prostatic carcinoma. Urology 34(4): 181-186, 1989

Radical external radio therapy for prostatic carcinoma. International Journal of Radiation Oncology, Biology, Physics 7(7): 885-890, 1981

Proton radiation as boost therapy for localized prostatic carcinoma. JAMA 241(18): 1912-1915, 1979

A comparison of treatments of squamous cell carcinoma of the base of tongue: surgical resection combined with external radiation therapy, external radiation therapy alone, and external radiation therapy combined with interstitial radiation. BrachyTherapy 3(4): 240-245, 2004

Prostatic carcinoma. External radiation therapy. Journal of the Kansas Medical Society 83(10): 479-483, 1982

Hormonal changes after localized prostate cancer treatment. Comparison between external beam radiation therapy and radical prostatectomy. Actas Urologicas Espanolas 40(9): 549-555, 2016

What is the best treatment for clinically localized prostate cancer: Radical prostatectomy, brachytherapy, or external beam radiation therapy?. Journal of Urology 179(4): 492, 2008

External radiation therapy of prostatic carcinoma and its relationship to hormonal therapy. Radiation Medicine 13(6): 297-300, 1995

Complications associated with preoperative radiation therapy and Iodine-125 brachytherapy for localized prostatic carcinoma. Urology 22(2): 123-126, 1983

Localized ureteral fibrosis: an unrecognized complication of radiation therapy for prostatic carcinoma. Journal of Urology 115(5): 610-611, 1976

Survival with localized carcinoma radical prostatectomy vs. radiation therapy. Urology 25(4): 347-349, 1985