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Reductive amination of aldehydes and ketones to their corresponding amines with N-methylpyrrolidine zinc borohydride



Reductive amination of aldehydes and ketones to their corresponding amines with N-methylpyrrolidine zinc borohydride



Tetrahedron Letters 50(6): 659-661



A simple and convenient procedure for reductive amination of aldehydes and ketones using N-methylpyrrolidine zinc borohydride (ZBHNMP) as a reducing agent is described. The reactions are carried out with 1 equiv of amine and 1 equiv of aldehyde or ketone using 1 equiv of ZBHNMP in methanol under neutral conditions at room temperature.

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Accession: 025358814

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DOI: 10.1016/j.tetlet.2008.11.102


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