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Researches on the permeability of frog-skin. I. On the assumption of irreciprocal permeability. II. On the effect of external conditions on the permeability of frogskin to salts. III. On the influence of temperature acidity and ionic composition of the applied solution. IV. On the effect of narcotics and some other experiments



Researches on the permeability of frog-skin. I. On the assumption of irreciprocal permeability. II. On the effect of external conditions on the permeability of frogskin to salts. III. On the influence of temperature acidity and ionic composition of the applied solution. IV. On the effect of narcotics and some other experiments



Japanese Jour Med Sci Hi Biophysics 1(4): 157-172, 173-185, 187-203, 205-216



Skin was isolated from the trunk of Rana nigromaculata; pieces of it were tied over the ends of 1 cm. glass tubes, the cut sides being covered with vaseline. The rates of penetration of Cl, and sometimes of NO3, were measured per unit area of skin surface exposed.[long dash]I. Penetration of these anions in either direction was increased by bathing the skin in distilled water or in sucrose solution. Inward and outward penetration appeared to be altered in parallel.[long dash]II. Permeability increased with either dilution or concentration of the Ringer's solution that bathed the skin's inner surface. Dilution with isotonic sucrose solution below a certain limit also increased the permeability. KC1 increased it reversibly[long dash]III. Temps. of 7[degree]-27[degree]C., and changes of pH from 4 to 10, had no influence on the penetration of Cl. Various cations modified the permeability to Cl in the way that K did, Na and Li having the least effects. Definite ratios of Ca and K assist Na in preserving the normal impermeability to Cl.[long dash]IV. Alcohol inhibited the increase of permeability caused by hypertonic solutions; thymol promoted the increase of permeability. When applied to the outer epidermal surface of the skin, all isotonic solutions equally increased the permeability to Cl.

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