Resistance to anticoagulants in view of the neurohumoral regulation of the blood coagulation and anticoagulation system
Kushelevskii, B.P.; Yastrebova, L.P.
Kardiologiya 5(1): 49-54
The resistance to anticoagulants even in a twofold increase of median therapeutic doses is one of the causes of their low effectiveness and even ineffectiveness. This phenomenon was observed in 25 patients with angina pectoris and myocardial infarction who have sustained a closed cerebral injury in the past. Studies of the blood coagulation and anticoagulation factors disclosed that such a resistance is due to a sharp decline of the heparin and fibrinolytic activity of the blood, which does not increase or rises slightly under the influence of anticoagulant administration as was noted in all patients with a normal resistance to anticoagulants. Confrontation of these observations with clinical and autopsy data makes it possible to associate the internal pathology of the closed injury with affection of the region of the third cerebral ventricle. A supposition that the reflex arch of the human neurohumoral regulation of the blood coagulation system is confined to this region is presented.