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Respiration of hepatic tissue during sleep caused by sodium amytal and phenobarbital

Respiration of hepatic tissue during sleep caused by sodium amytal and phenobarbital

Ukrain Biokhim Zhur 30(5): 761-769

Sodium amytal and phenobarbital were administered to rabbits in hypnotic doses (25 and 70 mg/kg respectively), or in toxic doses (40 to 45 and 100 to 120 mg/kg, respectively). The liver was removed from the animals when they were in a deep sleep. The O2 consumption of sections of the liver was determined with a Warburg apparatus. The activity of the dehydrases in homogenates of the liver was estimated by the decoloration of methylene blue. Hypnotic doses of the barbiturates considerably lowered the respiratory rate of the liver (61 to 39.9-40.7 mm3 of O2 for 30 minutes in 100 mg of tissue) without affecting the RQ. Toxic doses decreased the consumption of O2 to a lesser extent, but the RQ was definitely lowered. Hypnotic doses of both drugs sharply inhibited the dehydrase activity of the liver (23.5 to 12.7 gamma of methylene blue was decolorized in one minute). The difference between sodium amytal and phenobarbital is that the former greatly inhibits the activity only of the isocitric acid dehydrase.

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Accession: 025391950

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