Section 26
Chapter 25,395

Response of the isolated dogfish gastric mucosa to histamine

Adrian, C.; Hogben, M.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 124(3): 890-893


ISSN/ISBN: 0037-9727
PMID: 6023430
DOI: 10.3181/00379727-124-31879
Accession: 025394636

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The dogfish gastric mucosa is relatively refractory to histamine. An interstitial concentration of 2 mM is required to insure maximal secretion of acid. This concentration is high enough to suggest that if cholinergic excitation is mediated by the release of histamine, histamine is released within the oxyntic cells of this species. The dogfish mucosa is much less responsive to hog gastrin than is the bullfrog gastric mucosa.

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