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Role of urocanic acid in the metabolism of L-histidine



Role of urocanic acid in the metabolism of L-histidine



Archives of Biochemistry and Biophysics 119(1): 110-118



Despite the markedly increased excretion of urocanic acid induced in young male rats upon supplementing their 12% casein diets with 0. 05% of DL-ethionine, their rate of growth was not appreciably retarded after the first 4 days. The ethlonine markedly sup -pressed the activity of the liver urocanase, but had little effect upon the activity of hepatic histidine deaminase. The possibility that feeding extra L-histidine might increase the activities of histidine deaminase and urocanase was not substantiated. Similar increases occurred in normally fed controls. The levels of liver glycogen in control animals previously fed differing, but normal basal diets, varied with the diet, but the extra glycogen deposition produced by the administration of L-histidine was nearly the same in all. The net deposition after the administration of urocanic acid was much smaller and of questionable significance. Slow absorption of urocanic acid from the alimentary tract was at least partially responsible. Ethionine-fed rats produced little or no liver glycogen, whether given histidine, urocanic acid, or glutamlc acid. Such behavior is consistent with the suggestion that ethlonine may trap sources fo high energy, some of which are known to be required for glycogen synthesis.

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Accession: 025414920

Download citation: RISBibTeXText

PMID: 6052411

DOI: 10.1016/0003-9861(67)90435-3


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