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SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms


SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms



Bioinformatics 25(5): 655-661



ISSN/ISBN: 1367-4803

PMID: 19098027

DOI: 10.1093/bioinformatics/btn653

Multiple sclerosis (MS) susceptibility demonstrates a complex pattern of inheritance. Haplotypes containing HLA-DRB1*1501 carry most of the genetic risk. Epidemiological evidence implicating epigenetic factors includes complex distortion of disease transmission seen in aunt/uncle-niece/nephew (AUNN) pairs. Unexpectedly, in AUNN families we found that allele frequencies for HLA-DRB1*1501 were different between the first and second generations affected.

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Accession: 025418990

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