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Screening and identification of a peptide specifically targeted to NCI-H1299 from a phage display peptide library



Screening and identification of a peptide specifically targeted to NCI-H1299 from a phage display peptide library



Cancer Letters 281(1): 64-70



In this study, a NCI-H1299 (Non-Small Cell Lung Cancer, NSCLC) and a normal lung cell line (Small Airway Epithelial Cells, SAEC) were used for the subtractive screening in vitro with a phage display-12 peptide library. After three rounds of panning, there was an obvious enrichment for the phages specifically binding to the NCI-H1299 cells, and the output/input ratio of phages increased about 875-fold (from 0.4x10(4) to 3.5x10(6)).

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Accession: 025426664

Download citation: RISBibTeXText

PMID: 19327883

DOI: 10.1016/j.canlet.2009.02.021


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