Some aspects of acetylcholine metabolism in disturbances of the adrenal gland function in experiments
Probl Endokrinol 13(4): 68-72
Adrenalectomy in rats caused a rise of acetylcholine content in the heart and the intestine on the 7th[long dash]12th day after the operation and its fall in the brain and the heart on the 18th-20th day. On the 18th day cholinesterase activity increased in the brain,, heart and acetylcholinesterase activity increased in the erythrocytes; there was a fall of pseudocholinesterase activity in the blood serum. Changes of acetylcholine content and of the cholinesterase activity in adrenalectomized animals depended on deficiency of glucocorticoids, since hydrocortisone replacement therapy removed them. Experimentally-induced mineralocorticoid hypercorticism was accompanied by a fall of acetylcholine content in the brain, heart and intestine; also there was a reduction of pseudocholinesterase activity in the blood serum and a rise of acetylcholinesterase activity in the erythrocytes. Glucocorticoid hypercorticism was characterized by reduction of acetylcholine in the brain and heart, and by its rise in the intestine; enzymatic hydrolysis increased in the brain and fell in the intestine, erythrocytes and blood serum.