Some notes on Sevin-resistance in the house fly, Musca domestica and Musca domestica vicina

Ikemoto, H.

Botyu Kagaku 29(4): 68-73

1965


Accession: 025488879

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Abstract
An attempt has been made under laboratory conditions to obtain Sevin-resistant strain of the house fly Musca domestica using two different strains of SCR and Takatsuki, respectively. Selections were accomplished by the topical application of acetone solutions of Sevin to these house flies of both sexes, respectively. Selection pressure was maintained by varying the dose so that 10% to 30% of the flies can survive to propagate the next generation. In the case of "Takatsuki" strain of M. domestica, before the Sevin-pressure, the LD50 of this strain for Sevin was 4.53/ug+. With Sevin-pressure for three generations, Sevin-resistance developed to the extent that the maximum mortality does not exceed 32% with dosage more than 30μg. In the case of "SCR" strain of M. domestica before the Sevin-pressure, the LD50 of this strain for Sevin was 2.92/μg/. With Sevin-pressure for sixteen generations, Sevin-resistance developed to the extent where the maximum mortality does not exceed 13% with dosage more than 60μg. Two Sevin-resistant strains of the house fly generally showed no cross resistance to m-isopropylphenyl N-methylcarbamate, hydrochlorinated insecticides, organic phosphate insecticides. And Sevin-resistant strain of M. domestica (SCR) also showed no cross resistance to a-dl-trans-allethrin. Georghiou has shown that the house fly strains being resistant to m-isopropylphenyl N-methylcarbamate and Isolan exhibit following level of cross resistance to each compound; namely, high levels of cross resistance to substituted alkyl- and alkoxyphenyl N-methyl and N,N-dimethylcarbamates, biochemically limited cross resistance to certain heterocyclic carbamates, high levels of cross resistance to hydrochlorinated insecticides, limited cross tolerance or cross resistance to organic phosphate insecticides peculiar to each compound, and cross tolerance to allethrin. Cross resistance spectrum of Sevin-resistant house fly are significantly different to that of the house fly strains resistant to m-isopropylphenyl N-methylcarbamate and Isolan. From the result mentioned above, it may be concluded at this point that carbamate insecticides are divided into two groups and/or more.