Section 26
Chapter 25,536

Studien uber die Histiozyten in der Haut. II. Einfluss des Nervensystems auf die Histiozyten der Haut. III. Uber den Einfluss der Milz-exstirpation auf die Histiozyten der Haut. IV. Experimentelle Untersuchungen iiber das Schicksal der in die Kutis injizierten Kar-minzellen.

Koike, T.

Okayama Igakkwai Zasshi 42: 1255-1304, 1808-1816, 2058-2066


Accession: 025535353

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The cutis and the subcutaneous tissue normally contain a considerable number of histiocytes, which can be identified by granules of vital dye in their protoplasm. In the skin the histiocytes have various forms and are most numerous near the sebaceous glands, hair-follicles and blood vessels; their nuclei are excentric. Normally histiocytes can not be demonstrated in the epidermis.[long dash]II. Following the removal of pieces of N. ischiadicus and N. femoralis, phagocytosis of the dye by the histiocytes in the areas of distribution of both nerves was reduced. There was also a degeneration of the histiocytes, viz., a marked deposition of fat in the protoplasm, vacuole formation in the cell, and flaking of the dyestuff. After lateral hemisection of the lumbar cord no special changes in the histiocytes were found.[long dash]III. Within 7 days after splenectomy a slight disturbance of the function of the histiocytes appeared; the cells took up only small amounts of the dye. Cell-accumulations caused by inflammatory irritation were not so striking as in the controls. Such changes are especially striking 30-50 days after splenectomy. After blockage of the reticulo-endothelial system by the method of Amano, carmin was injected intracutaneously. The carmin-ingesting ability of the skin histiocytes showed a slight decrease; but the collargol in the cells was hard to find.[long dash]IV. Many of the carmin-cells, prepared after Hayakawa's method and introduced into the cutis, showed no special changes 24 hrs. after being injected, although a few of them had degenerated and had been taken up by the local histiocytes. Later however all the carmin cells were destroyed and the freed carmin picked up by the histiocytes of the local tissue. The author has obtained no proof that the carmin cells change into fibroblasts.

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