Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen
Waksman, B.H.; Pearson, C.M.; Sharp, J.T.
Journal of Immunology 85: 403-417
ISSN/ISBN: 0022-1767 PMID: 13782608 Accession: 025543322
A disseminated inflammatory disease affecting the joints, skin, eye and mucous membranes was produced in rats following injection with killed tubercle bacilli in oil. Intradermal inoculation and foot-pad inoculation in particular were more effective than other routes in producing this process. Litters of rats differed markedly in susceptibility. Animals less than 5 weeks of age appeared completely insusceptible. Rats with disease showed strong skin reactivity of the delayed type to tuberculin.