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Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen

Waksman, B.H.; Pearson, C.M.; Sharp, J.T.

Journal of Immunology 85: 403-417

1960

ISSN/ISBN: 0022-1767
PMID: 13782608
Accession: 025543322
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A disseminated inflammatory disease affecting the joints, skin, eye and mucous membranes was produced in rats following injection with killed tubercle bacilli in oil. Intradermal inoculation and foot-pad inoculation in particular were more effective than other routes in producing this process. Litters of rats differed markedly in susceptibility. Animals less than 5 weeks of age appeared completely insusceptible. Rats with disease showed strong skin reactivity of the delayed type to tuberculin.

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Related References

Waksman, B.H.; Bullington, S.J. 1960: Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. III. Lesions of the eye Archives of Ophthalmology 64: 751-762
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Pearson, C.M.; Waksman, B.H.; Sharp, J.T. 1961: Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. V. Changes affecting the skin and mucous membranes. Comparison of the experimental process with human disease Journal of Experimental Medicine 113: 485-510
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Mellinkoff, S.M.; Pearson, C.M.; Wood, F.D.; Eshelman, O.; Dixon, W. 1962: Studies of Polyarthritis Induced in Rats by Injection of Mycobacterial Adjuvant The American Journal of Clinical Nutrition 10(5): 398-402
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Geiler, G.; Keitel, W.; Franke, A. 1975: Comparative morphological studies on adjuvant arthritis induced in the extremities of rats, mice, and golden hamsters by intracutaneous injection of Freund's complete adjuvant Experimentelle Pathologie 10(1-2): 72-82
Joe, B.; Cannon, G.W.; Griffiths, M.M.; Dobbins, D.E.; Gulko, Pércio.S.; Wilder, R.L.; Remmers, E.F. 2002: Evaluation of quantitative trait loci regulating severity of mycobacterial adjuvant-induced arthritis in monocongenic and polycongenic rats: identification of a new regulatory locus on rat chromosome 10 and evidence of overlap with rheumatoid arthritis susceptibility loci Arthritis and Rheumatism 46(4): 1075-1085
Prakken, B.J.; van der Zee, R.; Anderton, S.M.; van Kooten, P.J.; Kuis, W.; van Eden, W. 1997: Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis Proceedings of the National Academy of Sciences of the United States of America 94(7): 3284-3289
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